| Toxicology Study |
Clinical Study Reference |
| 60-Day Subcutaneous Toxicity Study of Recombinant Adenovirus Expressing PDGF-B in C57B1/6 Mice.
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Phase I Study of H5.020CMV.PDGF-B to Treat Venous Leg Ulcer Disease.
David J. Margolis, Lee M. Morris, Maryte Papadopoulos, Linda Weinberg, Jennifer C. Filip, Stephanie A. Lang, Sachin S. Vaikunth and Timothy M. Crombleholme.
Molecular Therapy publication 28th July 2009.doi:10.1038/mt.2009.169 |
| A Single-Dose Toxicology Study of NP2 Administered Subcutaneously in BALB/c Mice with 90 Day Follow-up |
Herpes Vector-mediated Gene Transfer in the Treatment of Chronic Pain. Joseph C. Glorioso(1) and David J. Fink (2). Molecular Therapy (2008)17 1, 13-18 doi:10.1038/mt.2008.213
1. Dept of Microbiology and Molecular Genetics, University of Pittsburgh, Pennsylvania.
2. Dept of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
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| A Human Trial of HSV-mediated Gene Transfer for the Treatment of Chronic Pain. D Wolf, M Mata and DJ Fink Diamyd Inc., Pittsburgh, PA, USA and Dept of Neurology, Univ. of Michigan and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, MI USA Gene Therapy (2009), 1-6 |
| A Single-Dose 90 Day Biodistribution Study of Viral Test Article NP2 Administered Subcutaneously in BALB/C Mice |
A Human Trial of HSV-mediated Gene Transfer for the Treatment of Chronic Pain.
D Wolf, M Mata and DJ Fink
Diamyd Inc., Pittsburgh, PA, USA and Dept of Neurology, Univ. of Michigan and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, MI USA
Gene Therapy (2009), 1-6 |
| One-week Toxicity and Biodistribution Study of AAV2-SB-hRPE65 Following a Single Subretinal Injection in Cynomolgus Monkeys. |
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| RPE65 Canine Pre-Clinical Studies |
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| Toxicology and Biodistribution Study of Adenylyl Cyclase VI Gene Transfer for Congestive Heart Failure Summary of Findings |
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| A 90-Day Toxicology and Biodistribution Study of Viral Test Article NC3 Administered Intracranially in BALB/c Mice |
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| Direct Comparative Analysis of rAAV1 and rAAV5 Pseudotyped Vectors Using Aerosol Delivery of Firefly and Renila Luciferase Reporters Co-delivered to the Lungs of Chimpanzees. |
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| Biodistribution Report of rAAV6-CMV-SERCA2a Following Injection into the Heart in Canines |
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